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If you believe in the power of what science can do, join us in our endeavour to push the boundaries of science to deliver life-changing medicines.
澳门第一赌城在线娱乐正在不断推动科学的发展,以提供改变生活的药物,这些药物将对澳门第一赌城在线娱乐致力于治疗的疾病产生最大和最快的影响, prevent, modify and in the future, even cure. 只有加强澳门第一赌城在线娱乐对疾病生物学的理解,发现针对疾病驱动因素的新方法,澳门第一赌城在线娱乐才能在肿瘤学的主要治疗领域创造下一代治疗方法, Cardiovascular, Renal and Metabolism, and Respiratory and Immunology.
We are already leveraging the rapid advancements in science and technology to create new therapeutics, such as cell-based therapy, antibody therapeutics, and nucleotide-based therapeutics, for disease mechanisms which were previously considered difficult, if not impossible, to target.1 Additionally, we are working on integrating knowledge of drug candidates and their interactions with their target, 疾病的病理生理学和给药系统,以便设计先进的给药技术.2 Each new insight and every new piece of information brings us closer to creating better, more advanced and more effective treatments for patients.
与世界各地的合作者合作,正在帮助澳门第一赌城在线娱乐的科学家开拓药物发现的新方法. In fact, 30% of our early pipeline now consists of new drug modalities including oligonucleotides, mRNA and Anticalin® proteins.
选择与疾病驱动因素有密切联系的正确靶标仍然是澳门第一赌城在线娱乐在药物发现过程中做出的最重要的决定. Once this target is selected, 澳门第一赌城在线娱乐现在有了一个由传统分子和创新分子组成的工具箱,澳门第一赌城在线娱乐可以利用它们来瞄准新的生物学. You can explore our toolbox of modalities below.
澳门第一赌城在线娱乐在发现和开发口服小分子药物方面有着悠久的历史,利用创新的方法来设计和给药. 小分子可以被设计成通过各种作用模式参与生物目标,并在细胞内和细胞外发挥作用. 它们的分布可以进一步调整,以允许有或没有穿透大脑的全身暴露. 点击下面的瓷砖阅读更多澳门在线赌城娱乐对传统小分子的研究,这些小分子一直是澳门第一赌城在线娱乐业务的基石, to ground-breaking, new small-molecule approaches such as PROTACs and zirconium cyclosilicates.
抗体可以非常准确地靶向蛋白质,并且可以通过工程设计来提高特异性, potency and affinity. 澳门第一赌城在线娱乐正在扩大澳门第一赌城在线娱乐的抗体工程平台的范围,并设计新的和改进的治疗方法,如双特异性抗体和片段抗体,目的是获得难以达到的治疗靶点. 点击下面的图片,了解更多澳门在线赌城娱乐创造下一代抗体疗法的研究成果.
Through our long-standing expertise in protein engineering, we are advancing both conventional and novel classes of protein and peptide therapies. Because proteins are large molecules, 它们通常不具有细胞渗透性,传统上仅限于细胞外靶点和注射给药途径. Peptides constitute a smaller format of protein therapeutics. They are typically developed as small, specific and highly selective ligands for extracellular targets.
Through various collaborations, 澳门第一赌城在线娱乐不仅在探索开发传统的蛋白质疗法和多肽,而且还在探索潜在的创新疗法,如antialin®蛋白质和双环肽. Click the tiles below to read more about these novel drug modalities.
Recent advances in genomics has led to a myriad of potential new drug targets and with it, the opportunity for nucleotide-based therapeutics to have a real impact on disease. 澳门第一赌城在线娱乐正在探索一些nucleotide-based形式从寡核苷酸和RNA-based疗法使用CRISPR / Cas9作为一个潜在的治疗工具. Click the tiles below to read more about these novel drug modalities.
Behind every advancement we make, there is a team of dedicated scientists. Find out more about some of our researchers working at the cutting-edge of drug discovery:
1. Valeur E, Guéret SM, Adihou H et al. New Modalities for Challenging Targets in Drug Discovery. Angewandte Chemie. 2017. 56(35): 10294-10323.
2. Ashford M. Drug Deliv Transl Res. 2020 Oct 6. doi: 10.1007/s13346-020-00858-6. Online ahead of print.
If you believe in the power of what science can do, join us in our endeavour to push the boundaries of science to deliver life-changing medicines.
We know that however innovative our science, however effective our medicines and delivery, to achieve all we want to achieve, we cannot do it alone.
Veeva ID: Z4-58111
Date of preparation: September 2023